INTERACTION ENERGIES IN NON WATSON-CRICK PAIRS: AN AB INITIO STUDY OF G<FONT FACE=Symbol>·</FONT>U AND U<FONT FACE=Symbol>·</FONT>U PAIRS
نویسندگان
چکیده
منابع مشابه
Non-Watson-Crick base pairs in RNA-protein recognition.
The cellular functions of most RNA molecules involve protein binding, and non-Watson-Crick base pairs are hallmark sites for interactions with proteins. The determination of three-dimensional structures of RNA-peptide and RNA-protein complexes reveals the molecular basis of non-Watson-Crick base-pair recognition.
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We analyzed geometries and energies of 469 GC and 224 AT pairs occurring in 11 A-, 54 B- and 12 Z-DNA crystal structures. The most frequent hydrogen bond length conforms to the canonical value but distributions of the hydrogen bond lengths are unexpectedly wide. The average GC pair is rather compressed and opened into the double helix minor groove while an average AT pair has canonical dimensio...
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Nucleic acid duplexes containing non-Watson–Crick base pairs are of interest to several fields including structural biology, supramolecular chemistry, origin of life, and synthetic biology. An early observation of a natural non-Watson–Crick base pair was the tRNA–mRNA adenine–inosine wobble pair, and it is now known that purine–purine pairs occur frequently in natural RNAs, including ribosomes ...
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ژورنال
عنوان ژورنال: Journal of the Chilean Chemical Society
سال: 2005
ISSN: 0717-9707
DOI: 10.4067/s0717-97072005000100013